In this study, the efficient method was introduced for the preparation of copper-periodic mesoporous organosilica nanocomposites (Cu@MOS NCs) as a high performance heterogeneous nanocatalyst. Then the nanocomposite was characterized with various methods such as X-ray diffraction (XRD), BET analysis, SEM and EDS microscopy and thermogravimetric analysis (TGA). The Cu@MOS NC as nanocatalyst was applied for one-pot three component reactions of aromatic aldehydes, dimedone, and malononitrile for the effective and green synthesis of 2-amino-4H-benzo[b]pyran derivatives in high yields, with operational simplicity, environmental friendliness, wide applicability and reusability and easy recovery of the catalyst.